glucose detector noninvasive, new devices

Hello,
After I researched Mr. Ui Luu's device to measure the glucose level in the blood noninvasively, I was assigned to research for new devices that are an updated version of Mr. Ui Luu's device. I found a really interesting new device that uses different methods and techniques to give the glucose level in the blood noninvasively, and these devices can be installed in many different parts in or on the body.

Note; there some devices that will be installed right under the skin, so we might want to consider that as a semi-invasive device.

The devices that I found are the following:

Dexcom: Continuous Glucose Monitoring (CGM) systems track glucose levels throughout the day. CGM users insert a tiny sensor wire just under their skin using an automatic applicator. An adhesive patch holds the CGM sensor housing in place so the sensor can measure glucose readings in interstitial fluid throughout the day and night. A small, reusable transmitter connects to the sensor wire and sends real-time readings wirelessly to a receiver, so the user can view the information. With some systems, a compatible smart device with the CGM system app can serve as the display device. The receiver or compatible smart device displays current glucose levels, as well as historical trends in levels. The CGM receiver and/or compatible smart device can also be set to send custom alerts to the user when certain glucose thresholds are reached.


DiaMonTech: 

A patented technology works with an invisible infrared light beam that looks into the skin and counts glucose molecules.

DMT BASE: is available now. The technology is based on well-established physical methods in the field of spectroscopy. an expansion on these methods occurred to be able to detect glucose in the human body. This is a concept called “photothermal detection”.

MEASUREMENT PROCESS:

After the finger is placed gently on the sensor, a light beam is directed to it. Glucose in your skin transforms that light to heat. This minimal change in temperature (you won’t notice it) is measured by the detection system. the device then calculates the blood sugar level based on the temperature change.

GlucoTrack

Developed by Integrity Applications in Israel, GlucoTrack can measure blood sugar levels through a combination of ultrasonic, electromagnetic and thermal waves. To provide a readout, the sensor is clipped on the ear. The device is indicated for adults with type 2 diabetes and is currently approved in Europe, where the company has just recently started to commercialize the glucose monitor.

                                  

Eversense

Developed by Senseonics, Eversense is a subcutaneous implant that can last for up to 3 months. The device can measure glucose in the interstitial fluid under the skin of the arm by using a polymer that fluoresces in response to the levels of glucose. The data is then sent to a transmitter that displays glucose levels in real time.

GlucoWise

It is a sensor under development that could measure glucose levels by just placing it on the earlobe or the skin between the thumb and forefinger. The real-time measurements could then be sent directly to a smartphone app. 

By using radio waves to measure glucose levels, the developers believe the device should be more accurate than other wireless glucose monitors. The company behind it, MediWise, run a first trial in healthy volunteers and is now getting ready to test a prototype in diabetics.

GlucoSense

It is a spin-out of the University of Leeds, UK, that is developing a laser technology to monitor glucose levels. The device is made of a nano-engineered glass that fluoresces when stimulated by a low power laser.

When the glass is in contact with the user’s finger skin, the reflected fluorescent signal changes based on the concentration of glucose in their blood, giving a measurement in less than 30 seconds.

NovioSense

NovioSense is a Dutch startup working on a glucose sensor that is placed under the lower eyelid, from where it can wirelessly send glucose measurements directly to a smartphone. The device consists of a flexible metal coil of just 2cm in length that contains nanosensors inside. In turn, the coil is covered by a protective layer of soft hydrogel.

The coil could measure minute-to-minute changes in the glucose levels of tear fluid by using the same enzyme technology on which conventional glucose strip tests are based. The device has been tested in animals and the company is now planning clinical trials.

Google’s smart contact lens

Back in 2014, Google and Novartis’ eye care division partnered to develop a smart contact lens that could measure glucose levels. The lens would incorporate a thin microchip to measure glucose and an antenna to send the information to a smartphone.

However, there haven’t been any major updates on the project since then and it is not known when the first trials will start. Meanwhile, researchers in South Korea have been developing their own form of a glucose-sensing smart lens, which has been shown to work in animals.

I think this field is sophisticated but it needs more attention, these devices are amazing but I feel there is more that can be done, it can be more common.

Thank you,

Abdullah Albayati.